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Achondroplasia is one form of dwarfism caused by abnormal bone development. This is an autosomal dominant condition that is lethal if a developing...

Recall that dominant alleles are represented by capital letters and recessive alleles by lowercase letters.


We are told this condition is dominant but lethal when two copies are present (AA). Thus we know the dwarf male must have the heterozygous (Aa) genotype. A normal female will have zero copies of the dwarfism gene, which we write as an aa genotype. 


So a normal woman and a dwarf man will be as follows: Aa x aa.


If we cross these two genotypes, the resulting possible genotypes of their children will therefore be: Aa, Aa, aa or aa. This means two dwarf children and two normal height children.


So the predicted ratio of dwarf children to normal height children will be 2:2, which can be simplified as 1:1. 

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